Endocrine Abstracts

Pathologies of pituitary gland are often revealed by diabetes insipidus. Etiologies are, in first, tumors, inflammatory and granulomatosis diseases after, but stay idiopathic in 24% of French study, 52% of Italian study and 33% of Tunisian study.Case report: Mrs A., 53 years old, consults in 1998 because polyuria–polydipsia, without diabetes mellitus. She is hospitalized during 2 days and hydric restriction test shows the organic reality. The others...

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TSHR autoantibodies with stimulating (agonist) activity cause the hyperthyroidism of Graves’ disease, while the rarer blocking (antagonist) type TSHR autoantibodies are responsible for hypothyroidism in some patients. We have isolated four human monoclonal autoantibodies (MAbs) which bind the TSHR with high affinity. Two antibodies, M22 and K1-18 have potent thyroid stimulating activity, one MAb K1-70 has strong antagonist (blocking) activity and the fourth MAb 5C9 has st...

Bariatric surgery has become the most effective therapeutic option for morbid obesity (BMI > 40 or >35 with major complications). All established surgical techniques are followed by significant body weight reduction as well as clear improvement /remission of main obesity-associated comorbidities such as type 2 diabetes (DM2), dyslipidaemia, hypertension, sleep apnoea and cardiac dysfunction. Mixed restrictive-malabsorptive techniques, such as Roux-en Y-gastric bypass (...

Introduction: Prolactinoma account for 40% of all pituitary tumors. It is the most common cause of hyperprolactinemia. Infertility, galactorrhea and hirsutism are the significant symptoms. Polycystic ovary syndrome affects the 5–10% of the women in reproductive age. The most common symptoms are irregular menses, hirsutism and infertility. However, prolactinoma and PCOS association is rare. A case of PCOS and prolactinoma is reported.Case: A 21-year-...

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I have been the module leader for the Paediatric Endocrinology: exploring practice module for several years. Amongst those nurses who access or contribute to the course it is clear to see the wealth of knowledge, clinical expertise, enthusiasm for the subject area and professional commitment to delivering high quality nursing care to children, young people (CYP) and their families. Excellent examples of nursing care for CYP are presented in the assignments and every year I app...